COMPOSITION
Each gram contains
Gentamycin sulphate: 200 mg
Doxycycline hyclate: 200 mg
DESCRIPTION
GENTADEX 400 WSP is a synergistic combination of gentamicin and doxycycline designed to provide broad-spectrum antibacterial coverage. Gentamicin, an aminoglycoside antibiotic, exhibits bactericidal action primarily against gram-negative bacteria, including E. coli, Klebsiella, Pasteurella, and Salmonella species. Doxycycline, a tetracycline antibiotic, has bacteriostatic effects against a wide range of gram-positive and gram-negative bacteria, such as Campylobacter, Haemophilus, Pasteurella, Salmonella, Staphylococcus, and Streptococcus species. It is also effective against atypical pathogens, including Chlamydia, Mycoplasma, and Rickettsia species. The mechanism of action for doxycycline involves the inhibition of bacterial protein synthesis, leading to disrupted bacterial growth. Gentamicin remains unabsorbed in the gastrointestinal tract, providing a localized antibacterial effect, while doxycycline, with its strong affinity for lung tissues, ensures effective treatment of respiratory tract infections. This combination offers both intensive gastrointestinal and systemic antibacterial action, delivering rapid therapeutic benefits for a wide range of infections.
INDICATIONS
GENTADEX 400 WSP is indicated for the treatment of infections caused by microorganisms susceptible to gentamicin and/or doxycycline. It is particularly effective in treating gastrointestinal and respiratory tract infections in calves, lambs, pigs, and poultry. As a potent antibacterial solution, GENTADEX 400 WSP is highly effective in addressing a broad range of infectious diseases in these targeted animals.
CONTRA-INDICATIONS
Do not administer to animals with known hypersensitivity to aminoglycosides or tetracyclines.
Avoid use in animals with kidney or liver impairment.
Not recommended for animals with active microbial digestion, such as ruminants.
Not intended for animals producing milk or eggs for human consumption.
SIDE EFFECTS
Hypersensitivity reactions may include gastrointestinal disturbances and alterations in the intestinal flora.
Prolonged use at high doses can lead to neurotoxicity, ototoxicity, or nephrotoxicity.
Drug Incompatibility
Do not administer concurrently with penicillins, cephalosporins, quinolones, or cycloserine, as this may reduce efficacy or increase the risk of adverse effects.
DOSAGE AND ADMINISTRATION
For oral administration via feed or drinking water.
Poultry: 100 g per 300 liters of drinking water for 3 – 5 days.
Calves, lambs, and kids: 1 g per 50 kg bodyweight twice daily for 4 – 6 days.
Pigs: 100 g per 200 liters of drinking water for 4 – 6 days.
Mixed with feed, use the product immediately.
Mixed with drinking water, use the product within 24 hours.
WITHDRAWAL PERIOD
Meat:
Calves, lambs, and kids: 14 days
Pigs: 8 days
Poultry: 7 days
STORAGE
Store in a dry and dark place between 8 °C and 25 °C.
Store in closed packing.
Keep medicine away from children.
PACKING
20 kg bags, 1 kg pouches.
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